Skip to main content
. 2008 Apr 9;28(15):3947–3957. doi: 10.1523/JNEUROSCI.5667-07.2008

Figure 3.

Figure 3.

In vivo ChIP demonstrates that uH2A association with gene promoters inversely correlates with transcriptional activity in R6/2. A, No difference in uH2A association with Drd2, Sst, and Grin1 gene promoters between 4 week wild-type and transgenic R6/2 brain regions, except for decreased uH2A association with Sst gene promoter in transgenic cortex (n = 3 animals per group; *p < 0.05). uH2A enrichment in Grin1 gene promoter in hippocampus (hippo) was below a detection limit in both wild-type and transgenic mice. B, Increased uH2A association with Drd2 gene promoter in 8 week transgenic striatum, hippocampus, and cortex but not cerebellum (cbll) compared with wild-type. Increased uH2A association with Sst gene promoter in 8 week transgenic striatum and cortex, but not in hippocampus or cerebellum (n = 3 animals per group; *p < 0.05). C, Increased uH2A association with Drd2 gene promoters in all brain regions of 12 week transgenic R6/2 compared with wild type but increased uH2A association with Sst gene promoter in 12 week R6/2 striatum and hippocampus (n = 3 animals per group; *p < 0.05). D, Increased uH2A association with expressed-WT-only Inhbc and Dnaj3b gene promoters but decreased uH2A association with expressed-Tg-only Gabt and upregulated-Tg CCK gene promoters in all brain regions of 12 week transgenic mice, except for CCK in transgenic cerebellum, compared with wild type (n = 3 animals per group; *p < 0.05). Error bars indicate SEM. TG, Transgenic; WT, wild type; hippo, hippocampus; cbll, cerebellum; IP, immunoprecipitation.