Figure 3.
Biochemical consequences of folate deficiency and Ung genotype. A, Uracil misincorporation in DNA; ANOVA for genotype: F (1,29) = 5.6, p = 0.02. B, BDNF protein levels in hippocampus; ANOVA for interaction: F (1,31) = 16.6, p < 0.0005. C, GSH levels in whole cerebral hemispheres; ANOVA for interaction: F (1,20) = 5.6, p = 0.03. D, GSH levels in cerebellum; ANOVA for interaction: F (1,20) = 20.4, p = 0.0002. *p < 0.05, ND versus FD; # p < 0.05, Ung+/+ versus Ung−/−; + p < 0.05 for interaction; two-way ANOVA and Tukey post hoc; n = 5–9 animals per group.