Figure 7.

Behavioral analysis. Behavioral analyses were performed after 3 months on the experimental diet (control or folate-deficient diet). A, B, Latencies (A) and path lengths (B) of Ung+/+ and Ung−/− animals on folate-deficient or control diet during the acquisition phase of the Morris water maze. There were significant effects of diet and trial number on escape latency and path length (repeated-measures ANOVA; see Results). C, Target preference during probe trial. D, E, Latency to float (D) and time floating (E) in the behavioral despair test (Porsolt). F, Latency until first entry into the open arms of an elevated plus maze. ^# p < 0.05, Ung+/+ versus Ung−/−. n = 6–14 animals per group. For statistical analysis, see Results.