Figure 1.

Classification of genes showing significant changes in expression in the spinal cord after sciatic nerve injury. About one-third of upregulated genes are responsible for the inflammatory/immunological processes, whereas only a small amount of genes belonging to this category was downregulated. A large number of genes involved in signaling and metabolism were upregulated and downregulated. A fewer number of genes regulating cell structure, translation/transcription, and DNA repair functions are in rather equal number upregulated or downregulated. A large number of genes with unknown function have a different expression after sciatic nerve injury.