Figure 3.

Expression of genes regulated by IFN-γ or IFN-α after partial sciatic nerve ligation (PNL) was upregulated. A, The increase in expression level of IFN-γ-regulated genes was more intensive in CB₂ ^−/− than in CB₂ ^+/+ mice, whereas the upregulation in IFN-α-regulated genes was less intensive in CB₂ ^−/− animals. B, Taqman real-time PCR analysis of the expression of three GTPase regulated genes also showed a stronger expression change in CB₂ ^−/− than in CB₂ ^+/+ mice after neuropathy. wt-i, Ipsilateral paw of CB₂ ^+/+ mice; wt-c, contralateral paw of CB₂ ^+/+ mice; ko-i, ipsilateral paw of CB₂ ^−/− mice; ko-c, contralateral paw of CB₂ ^−/− mice.