Figure 4.

B. melitensis infection induces astrocyte hypertrophy. The total length of processes of astrocytes from infected macaques were increased in both gray and white matter (A, G). Similarly, the volume of the processes was increased (B, H). This was coincident with a hypertrophied cell body (C, I). It was curious that there were no changes in the number of primary processes (D, J). Therefore, the increased arbor was a result of increased branching (E, K) and thus, tip quantity (F, L) in astrocytes of macaques infected with Brucella. ^*p < 0.05.