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. 2013 Dec 2;3:3388. doi: 10.1038/srep03388

Figure 1. Induction of ER stress in glial cells.

Figure 1

Primary cultured mouse glial cells were treated with a specific ER stress-inducing reagent, tunicamycin (Tm: 1 μg/mL), and analyzed for the activation of UPR-related proteins. The treatment of glial cells with tunicamycin for 5 h caused the activation of IRE1 and PERK. A spliced form of XBP1 was increased 18 h after the tunicamycin treatment. CHOP and GRP78 were increased 24 h after the tunicamycin treatment. Cropped blots were run under the same experimental conditions.