Table 3. Serum TRAcP5b activity and PINP concentration.
| Age N: fl/fl, ΔOB/ΔOB |
Male mice |
Female mice |
|||
|---|---|---|---|---|---|
| 3 months | 6 months | 3 months | 6 months | ||
| |
|
8,8 |
8,7 |
6,9 |
6,12 |
| TRAcP (U ml−1) | ARfl/fl | 2.54±0.22 | 3.51±0.62 | 4.36±0.36 | 4.14±0.51 |
| ARΔOB/ΔOB | 3.84±0.24** | 2.49±0.33 | 5.07±0.72 | 3.31±0.43 | |
| PINP (ng ml−1) | ARfl/fl | 49.79±5.68 | 40.10±3.52 | 61.52±6.59 | 32.55±3.18 |
| ARΔOB/ΔOB | 65.62±3.45* | 35.90±2.03 | 50.73±5.44 | 25.71±2.27 | |
Abbreviations: AR, androgen receptor; PINP, procollagen 1 N-terminal peptide; TRAcP5b, tartrate-resistant acidic phosphatase 5b.
Analysis of serum TRAcP5b and PINP. In 3-month-old ARΔOB/ΔOB male mice the serum TRAcP5b activity was significantly elevated when compared with ARfl/fl mice. In addition, serum PINP concentrations were elevated in these mice.
*P<0.05, **P<0.01 when the values of the same age group were compared between the genotypes. Data represent means±s.e.m.