Figure 2.

Increased severity of the cortical phenotype in mice with broader Gja1 ablation along the osteogenic lineage. Data are derived from previously published results of independent studies using different stage-specific promoters to drive Cre-mediated Gja1 ablation; Dermo1/Twist 2 (Tw2);22 2.3 kb fragment of Col1A1 (Col1A);39 human osteocalcin (OC)27 and Dmp1.27 Percent difference relative to the respective wild-type (WT) controls in (a) marrow area; (b) total area and (c) cortical thickness. *Significantly different from respective WT littermates, P<0.05 (based on data reported in each original publication).