Table 2.

Cyanation of heteroaryl halides^[[a],[b]]

L1 95% (0.7% P1)	L2 97% (1% P2)	L2 93% (2% P2)	L2 64% (4% P2)[c]
L2 66% (1.6% P2)[d]	L2 91% (4% P2)	L2 91% (4% P2)	L2 92% (1.4% P2)
L2 93% (1% P2)	L3 64% (5% P3)[e]	L2 94% (4% P2)	L3 99% (1.5% P3)

^[a]Reaction conditions: aryl chloride (1 mmol), K₄[Fe(CN)₆]•3H₂O (0.5 equiv), precatalyst (× mol %), ligand (× mol %) KOAc (0.125 equiv), dioxane (2.5 mL), H₂O (2.5 mL).

^[b]Isolated yields, average of 2 independent runs.

^[c]0.5 equiv KOAc.

^[d]Low yield due to product volatility.

^[e]Isolated as HCl salt, 95:5 mixture of HetArCN:HetArBr.