Table 1.
Short-term effect of different doses of nebulized epinephrine on hemodynamic variables, arterial lactate, and glucose concentrations in healthy sheep
| Time After Epinephrine Nebulization (mins) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Variables | 0 | 1 | 2 | 3 | 4 | 5 | 10 | 15 | 60 |
| Mean arterial pressure, mm Hg | |||||||||
| Epi 2 mg | 107 ± 6 | 107 ± 6 | 107 ± 6 | 106 ± 7 | 104 ± 7 | 106 ± 8 | 104 ± 7 | 107 ± 6 | 106 ± 5 |
| Epi 4 mg | 103 ± 5 | 104 ± 7 | 105 ± 7 | 104 ± 7 | 104 ± 6 | 104 ± 6 | 102 ± 6 | 102 ± 7 | 102 ± 5 |
| Epi 6 mg | 100 ± 6 | 105 ± 8 | 102 ± 7 | 103 ± 6 | 102 ± 7 | 102 ± 7 | 102 ± 8 | 105 ± 7 | 101 ± 4 |
| Heart rate, bpm | |||||||||
| Epi 2 mg | 98 ± 12 | 101 ± 15 | 101 ± 15 | 99 ± 14 | 101 ± 14 | 100 ± 14 | 102 ± 14 | 98 ± 16 | 99 ± 15 |
| Epi 4 mg | 94 ± 14 | 90 ± 12 | 91 ± 12 | 95 ± 13 | 96 ± 15 | 96 ± 15 | 97 ± 15 | 96 ± 15 | 95 ± 15 |
| Epi 6 mg | 90 ± 12 | 88 ± 12 | 89 ± 12 | 89 ± 11 | 89 ± 12 | 91 ± 12 | 93 ± 14 | 92 ± 13 | 89 ± 13 |
| Lactate, mmol/L | |||||||||
| Epi 2 mg | .9 ± .2 | — | — | — | — | — | — | .8 ± .2 | .7 ± .3 |
| Epi 4 mg | .8 ± .2 | — | — | — | — | — | — | 1.5 ± .5 | 1.5 ± .6 |
| Epi 6 mg | .7 ± .2 | — | — | — | — | — | — | 1.9 ± .7a | 2.2 ± .6a |
| Glucose, mg/dL | |||||||||
| Epi 2 mg | 75 ± 8 | — | — | — | — | — | — | 78 ± 5 | 76 ± 5 |
| Epi 4 mg | 72 ± 6 | — | — | — | — | — | — | 94 ± 11a | 111 ± 10a |
| Epi 6 mg | 76 ±3 | — | — | — | — | — | — | 98 ± 17a | 137 ± 11a |
Epi, epinephrine.
a
p < .05 vs. baseline (0 min).