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. Author manuscript; available in PMC: 2013 Dec 2.

Published in final edited form as: Crit Care Med. 2011 Apr;39(4):10.1097/CCM.0b013e318207ec52. doi: 10.1097/CCM.0b013e318207ec52

Table 2.

Effects of different doses of nebulized epinephrine on the degree of lung injury after smoke inhalation

	Time After Injury (hrs)

Degree of Lung Injury	0	3	6	12	18	24	36	48
Pao₂/Fio₂, mm Hg
Saline	497 ± 13	407 ± 61	431 ± 55	439 ± 49	438 ± 42	393 ± 66	275 ± 65	192 ± 43
Epi 2 mg	475 ± 13	503 ±7	568 ± 21	556 ± 10	517 ± 30	454 ± 127	314 ± 120	222 ± 79
Epi 4 mg	528 ± 21	517 ± 24	574 ± 28	517 ± 51	485 ± 64	470 ± 64	442 ± 92^a	405 ± 65^a
Shunt fraction, Qs/Qt
Saline	.16 ± .01	.21 ± .02	.18 ± .02	.18 ±.01	.19 ± .03	.23 ± .05	.35 ± .07	.34 ± .06
Epi 2 mg	.17 ± .02	.18 ± .01	.15 ±.01	.15 ± .02	.15 ± .02	.23 ± .10	.30 ±.11	.28 ± .10
Epi 4 mg	.17 ± .02	.19 ± .02	.15 ±.01	.17 ± .03	.17 ± .03	.16 ± .02	.19 ± .04^a	.19 ± .02^a
Peak airway pressure, cmH₂O
Saline	20 ± 1	19 ± 1	19 ± 1	20 ± 1	21 ± 1	21 ± 1	29 ± 3	31 ± 4
Epi 2 mg	19 ± 1	18 ± 1	19 ± 2	20 ± 2	21 ± 3	24 ± 5	27 ± 5	27 ± 7
Epi 4 mg	20 ± 1	19 ±2	19 ± 1	19 ± 1	20 ± 2	19 ±2	23 ± 2^a	22 ± 2^a
Pause airway pressure, cmH₂O
Saline	19 ± 0	18 ± 1	17 ± 1	18 ± 1	18 ± 1	19 ± 1	25 ±3	28 ± 4
Epi 2 mg	18 ± 1	17 ± 0	17 ± 2	18 ± 2	19 ± 2	23 ± 6	25 ± 4	26 ± 6
Epi 4 mg	17 ± 2	17 ± 2	17 ± 1	16 ± 1	17 ± 1	17 ± 2	20 ± 2	20 ± 2^a

Epi, epinephrine.

^a

p < .05 vs. saline.