Figure 4.

TEM images of the high-pressure frozen/freeze-substituted and plastic sectioned HeLa cells that were either untreated (A) or incubated with 500 μM of precursor 1a (B). (C–F) the same as in (the top row), but the ultrastructure is shown at higher magnification. Note the pools of low electron dense (black arrowheads) and electron dense material (white arrowheads) in the treated cells. N, nucleus; M, mitochondria; G, golgi stack. Scale bars: 2 μm (top), 500 nm (C–F).