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. 2013 Nov 8;110(48):19378–19383. doi: 10.1073/pnas.1314030110

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Fig. 5. — Dependence of single-photon response on spontaneous PDE activation, cyclase feedback, PDE density, and outer segment radius. (A) Ten single-photon response simulations for a mouse rod with and . (B) Mean, SD, and CV of the mouse peak response amplitude with respect to the WT situation depicted in Fig. 4B as a function of with constant achieved by adapting k_sp (Eq. 2). Values are computed from 100 simulations. (C) Mean, SD, and CV as a function of calcium feedback on guanylyl cyclase. (D) Ten single-photon response simulations for a toad rod with a fourfold reduced OS radius and . is reduced by a factor of 16, but k_li and k_sp are increased 16-fold due the higher encounter rate. (E) Mean, SD, and CV as a function of the PDE density. and β_d both change (k_sp is unchanged). (F) Twenty single-photon response simulations for a mouse rod with fivefold reduced PDE density such that and .

Inline graphic — Dependence of single-photon response on spontaneous PDE activation, cyclase feedback, PDE density, and outer segment radius. (A) Ten single-photon response simulations for a mouse rod with and . (B) Mean, SD, and CV of the mouse peak response amplitude with respect to the WT situation depicted in Fig. 4B as a function of with constant achieved by adapting k_sp (Eq. 2). Values are computed from 100 simulations. (C) Mean, SD, and CV as a function of calcium feedback on guanylyl cyclase. (D) Ten single-photon response simulations for a toad rod with a fourfold reduced OS radius and . is reduced by a factor of 16, but k_li and k_sp are increased 16-fold due the higher encounter rate. (E) Mean, SD, and CV as a function of the PDE density. and β_d both change (k_sp is unchanged). (F) Twenty single-photon response simulations for a mouse rod with fivefold reduced PDE density such that and .