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. 2013 Nov 11;110(48):19472–19477. doi: 10.1073/pnas.1318172110

Fig. 1.

Fig. 1.

Comparison of luciferase reporter assay data with transcriptional activities of the endogenous gene copies. (A) Scheme of luciferase reporter constructs. (B) Promoter activities of LTR+ and LTR− constructs in Tera-1, NGP127, HepG2, and A549 cell lines (normalized to the SV40 promoter activity). (C) mRNA levels of SOCS4, PRODH, and KIAA1919 genes in cell lines measured by qRT-PCR relative to the endogenous β-actin (ACTB) gene expression. (D) Promoter activities of human and chimpanzee PRODH upstream regions. LTR−, human PRODH promoter region; LTR+, human PRODH promoter region including hsERV LTR; Chimpanzee, orthologous chimpanzee PRODH promoter (lacking hsERV). Data show means ± SD of three independent experiments.