Fig. 2.

T-cell response in NOD-Tg bGH mice. (A) NOD-Tg bGH mice show standard DTH responses. Footpad swelling at several times postchallenge in NOD-Tg bGH (dark gray, n = 6) and NOD mice (light gray, n = 6). Swelling was calculated as the percentage of footpad thickness compared with the baseline at t = 0. Values shown are mean ± SD. Student t test showed no significant differences at any time. (B) Circulating cytokine levels in 4-mo-old NOD (n = 12) and NOD-Tg bGH (Tg) (n = 11) mice. Individual and mean values are shown. Student t test, *P < 0.05, ***P < 0.001. (C) Ratios between Th2/Th1 and Th17/Th1 profiles, assessed by circulating cytokines quantification, in NOD (light gray bars, n = 12) and NOD-Tg bGH (dark gray, n = 11) mice. Values have been normalized to NOD mice data. Student t test, **P < 0.01.