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Adapter protein model of Rip1 substrate specificity. Ppr1 binds to both the Rip1 PDZ domain and the C terminus of the RsmA Rip1 substrate. Rip1 is tethered to RsmA by Ppr1 through the Rip1-PDZ, thereby holding Rip1 inactive. S1 cleavage of RsmA, which is not inhibited by Ppr1, releases the inhibitory effect of Ppr1 on the PDZ domain, allowing Rip1 cleavage. The model predicts additional unidentified substrate-specific adapters that tether Rip1 to Anti-SigK and Anti-SigL.
