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. Author manuscript; available in PMC: 2013 Dec 2.
Published in final edited form as: Structure. 2009 Nov 11;17(11):10.1016/j.str.2009.09.011. doi: 10.1016/j.str.2009.09.011

Figure 1. Structure of aptamer ARC1172 in complex with VWF A1 domain.

Figure 1

(A) Nucleotide sequence of ARC1172. Yellow shading indicates the nucleotides that contact the VWF A1 domain; squares below the sequence identify nucleotides in the consensus sequence that are required for high-affinity binding to VWF; triangles indicate nucleotides that do not tolerate 2′-O-methyl modification (Diener and Lagassé, 2006). (B) Cartoon representation based on the space group P212121 structure. The a-helices (Arabic) and (3-strands (Roman) within the VWF A1 domain are numbered. Nucleotides within 4.2 Å of the VWF A1 domain are colored yellow; nucleotides involved in non-canonical base pairs are labeled and shown by ball and stick. (C) Ball and stick representation of non-canonical base pairs and their composite omit electronic density map at a contour level of 1.0 σ. The dashed lines in cyan indicate hydrogen bonds.