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Effect of 7,3′,4′-THIF on the expression of PAR-2, filaggrin, and IL-4 in skin lesions. Immunohistochemical analysis of (a) PAR-2, (b) filaggrin, and (c) IL-4. Skin lesions were evaluated under a microscope at 100x magnification. Scale bar: 50 μm. (A) Untreated control group; (B) DFE-treated group; (C) DFE plus low-dose 7,3′,4′-THIF (4 mg/kg); (D) DFE plus high-dose 7,3′,4′-THIF (20 mg/kg).
