Table 3.
Geometric mean (90% CI) relative bioavailability of coadministered chloroquine and tafenoquine compared with chloroquine or tafenoquine administered alone
| Treatment* | AUC0–∞ (ng h ml−1) | AUC0–t (ng h ml−1) | AUC0–24 (ng h ml−1) | Cmax (ng ml−1) | t1/2 (h) | ||
|---|---|---|---|---|---|---|---|
| Comparison: CQ/TQ vs. CQ | |||||||
| Day 2 | Day 3 | Day 2 | Day 3 | Day 3 | |||
| CQ | 1.00 (0.84, 1.18) | 0.99 (0.83, 1.18) | 0.96 (0.82, 1.13) | 1.06 (0.90, 1.24) | 0.89 (0.74, 1.08) | 1.04 (0.86, 1.25) | 0.94 (0.78, 1.12) |
| DQ | 1.19 (0.79, 1.79) | 1.08 (0.79, 1.49) | 0.89 (0.69, 1.15) | 0.97 (0.75, 1.25) | 0.85 (0.66, 1.08) | 0.92 (0.72, 1.17) | 1.20 (0.79, 1.82) |
| Comparison: CQ/TQ vs. TQ | |||||||
| TQ | 0.98 (0.84, 1.14) | 0.98 (0.85, 1.13) | 1.24 (1.04, 1.46) | 1.12 (0.94, 1.32) | 1.38 (1.17, 1.64) | 1.13 (0.96, 1.34) | 1.06 (0.94, 1.20) |
Abbreviations are as follows: AUC0–24, area under the plasma concentration vs. time curve from 0 to 24 h; AUC0–∞, area under the plasma concentration vs. time curve from zero to infinity; AUC0–t, area under the plasma concentration vs. time curve from zero to the last quantifiable time point; CI, confidence interval; Cmax, maximal concentration; CQ, chloroquine; DQ, desethylchloroquine; and TQ, tafenoquine.
Treatment regimen: CQ 600 mg on days 1 and 2 and 300 mg on day 3; TQ 450 mg on days 2 and 3; combination therapy, CQ 600 and 300 mg concomitantly administered, on days 2 and 3, respectively, with TQ 450 mg.