Figure 1.
Conceptual representation of the structural model. CL, systemic clearance; DGI, gastrointestinal tract absorption compartment; Dmed, intermediate lung absorption compartment; Dslow, slow lung absorption compartment; FLUNG, bioavailability after inhalation with concomitant charcoal treatment compared with i.v.; Ffast, Fmed, Fslow, relative contributions of the three different lung absorption processes to total lung absorption; FGI, fraction of the dose absorbed through gastrointestinal tract; i.v., intravenous; KGI, Kmed, Kslow, absorption rates from the different absorption compartments; V1, central plasma compartment; V2, V3, peripheral pharmacokinetic compartments; Q1, Q2 intercompartmental clearances