Table 4.

Simulation of Study 2

Parameter	Abbreviation	Units	Predicted	Study report
Maximal concentration at steady state	Cmax,ss	pg ml−1	216 (129)	216 (148) [n = 24]
Area under the concentration–time curve from 0 to 24 h at steady state	AUC0–24 h,ss	h pg ml−1	653 (328)	558 (228) [n = 24]
Minimal concentration at steady state	Cmin,ss	pg ml−1	16.9 (9.24)	14.9 (5.24) [n = 24]

In Study 2, glycopyrronium 50 μg was administered once daily for 14 days. Data from the study report are arithmetic means (SD) of individual noncompartmental values [n], while predicted data are medians of arithmetic means and SD from simulations with 50 repeated trials and 50 subjects each.