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Effect–time profiles of the mean (and SD) change from baseline (%) for total lymphocyte count after single-dose administration of placebo (n = 12) or ponesimod at doses of 1, 3, 8, 20, 50 or 75 mg (n = 6 per dose group). 
, 1 mg; 
, 3 mg; 
, 8 mg; 
, 20 mg; 
, 50 mg; 
, 75 mg; 
, placebo
