Table 2.

Baseline corrected values from the evoked potential average analysis. Values are displayed as the average percentage of change from baseline with 95% confidence interval in square brackets

Feature	24 h	48 h	72 h	144 h
Buprenorphine
Delta	−5.8 [−44.6, 33.1]	14.6 [−33.9, 63.1]	28.8 [−22.8, 80.4]	25.6 [−28.9, 80.0]
Theta**	5.3 [−33.5, 44.2]	46.0 [−2.5, 94.5]	60.1 [8.4, 111.7]	73.3 [18.7, 127.7]
Alpha***	4.0 [−34.8, 42.8]	30.6 [−17.9, 79.1]	35.0 [−16.6, 86.6]	46.6 [−7.8, 101.0]
Beta*	7.1 [−31.7, 46.0]	16.0 [−32.5, 64.5]	16.5 [−35.1, 68.2]	10.1 [−44.3, 64.5]
Fentanyl
Delta	−9.8 [−48.6, 29.0]	2.1 [−46.4, 50.6]	2.4 [−49.2, 54.0]	10.3 [−44.1, 64.8]
Theta*	−6.2 [−45.0, 32.6]	12.1 [−36.4, 60.6]	24.9 [−26.7, 76.5]	20.8 [−33.7, 75.2]
Alpha	1.1 [−37.8, 39.9]	15.9 [−32.6, 64.4]	25.9 [−25.7, 77.5]	21.6 [−32.8, 76.0]
Beta	−0.6 [−39.5, 38.2]	5.2 [−43.3, 53.7]	3.2 [−48.5, 54.8]	5.8 [−48.6, 60.3]
Placebo
Delta	5.6 [−29.4, 40.6]	6.2 [−26.1, 38.6]	−1.4 [−34.3, 31.5]	4.6 [−33.1, 42.3]
Theta	3.6 [−31.4, 38.6]	4.8 [−27.5, 37.2]	5.3 [−27.6, 38.2]	16.0 [−21.7, 53.7]
Alpha	1.8 [−33.2, 36.8]	0.7 [−31.7, 33.1]	1.4 [−31.5, 34.4]	8.8 [−28.9, 46.5]
Beta	−2.3 [−37.3, 32.7]	−2.4 [−34.8, 30.0]	−3.9 [−36.8, 29.0]	−1.5 [−39.2, 36.2]

^*P < 0.05.

^**P < 0.01.

^***P < 0.001.