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. 2013 Dec 2;4:407. doi: 10.3389/fimmu.2013.00407

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Copyright © 2013 Pérez, Romeu, Cabrera, González, Batista-Duharte, Labrada, Pérez, Reyes, Ramírez, Sifontes, Fernández and Lastre.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Antibody response induced by AFCo1 plus Ovalbumin (Ova) by nasal (i.n) and intramuscular (i.m) routes. (A) IgG; (B) IgG1; and (C), IgG2a. BALB/c mice were distributed in two immunized groups and a control group. The first group was immunized with three i.n doses (0, 7, 14 days) of AFCo1 + Ova (25 μg/20 μg in 25 μL, 12.5 μL through each nostril). The second was treated with two i.m doses (0, 14 days) of AFCo1 + Ova (12.5 μg/10 μg in 50 μL per animal). The control received Ova i.n or i.m at 20 or 10 μg, respectively. Serum samples were taken 15 days after the last dose and antibody determination was carried out by ELISA. The figure shows the average and standard deviation of the mathematical relationship of values (OD) of two determinations in three independent experiments. The different p denote significant differences according to a Tukey multiple comparison test (p < 0.05).