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. Author manuscript; available in PMC: 2014 Nov 15.
Published in final edited form as: J Immunol. 2013 Oct 11;191(10):10.4049/jimmunol.1300456. doi: 10.4049/jimmunol.1300456

Figure 5. BC-1215 lessens severity of H1N1 influenza pneumonia.

Figure 5

A–D. C57BL6 mice were challenged with H1N1 (105 pfu/mouse, i.t.) for up to 9 d. For BC-1215 treatment, a stock solution (5 mg/ml) was added to drinking water (containing 2% sucrose) to the final concentration of 30 µg/ml. Lung mechanics were measured at day 5 using a FlexiVent (A–C). D. Survival studies of mice administered i.t. with H1N1 (105 pfu/mouse, n=8 mice/group). Mice were then euthanized and lungs were lavaged with saline, harvested, and then homogenized. Cell counts and lavage protein were measured in (E, F). G. Gross images of lungs from vehicle or BC-1215 treated mice. H. H&E staining was performed on lung samples. The data represent n=5–8 mice/group, *P<0.05 versus H1N1.