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. Author manuscript; available in PMC: 2014 Nov 1.
Published in final edited form as: Exp Eye Res. 2013 Oct 14;116:10.1016/j.exer.2013.10.006. doi: 10.1016/j.exer.2013.10.006

Figure 2.

Figure 2

ERG amplitudes as a function of age in normal and CLN2-affected dogs. ERG a-wave amplitude from 10 cd.s/m2 scotopic (A), and 3 cd.s/m2 photopic (B) recordings. Significant deficits in a-wave amplitude are not present until 10 months of age and only with scotopic recordings. ERG b-wave amplitude from scotopic rod responses (C), scotopic mixed responses from rods and cones at 10 cd.s/m2 (D), and photopic cone (E) and 30 Hz flicker recordings (F). Significant differences in b-wave amplitude exist even in early stages of disease (†, p<0.001; *, p<0.005; ‡, p<0.05). Error bars represent SEM.