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Baseline pupil diameter in anesthetized normal and CLN2-affected dogs between 4 and 10 months of age. Baseline diameter is significantly reduced in 10 month old affected dogs compared to 10 month old normal dogs (*, p<0.01). Due to the development of severe retinal lesions and euthanasia prior to 10 months of age for some dogs, sample size for the CLN2-affected group was reduced at 8 months (n=8) and 10 months (n=5) of age.
