Skip to main content
. Author manuscript; available in PMC: 2014 Nov 1.
Published in final edited form as: Exp Eye Res. 2013 Oct 14;116:10.1016/j.exer.2013.10.006. doi: 10.1016/j.exer.2013.10.006

Figure 9.

Figure 9

The rate of secondary redilation is reduced in CLN2-affected dogs at 8 and 10 months of age. (A) Sample PLR traces from 10 month old dogs shown as percent of baseline pupil area using a 15 log photons/cm2/s flash. The normal dog pupil gradually redilates to its baseline size (black plot) while the pupil from the affected dog maintains its constricted size for well over 85 seconds after light offset (gray plot). The vertical dashed line represents stimulus onset. (B) The rate of change in pupil diameter (mm/s) during secondary redilation, after a 15 log photons/cm2/s flash, was decreased in 8 and 10 month old affected dogs (*, p<0.025) indicating that constriction persists longer after light offset.