Figure 6. IL-17A neutralization alleviated DEP exacerbation of HDM-induced airway responses.
(A) Mice were given rat anti-murine IL-17A (200ug; M210) or an IgG1 control antibody intratracheally during FIDM±DEP challenges. (B) AHR was assessed 24h after the last exposure to HDM±DEP. (C) AHR following the last methacholine dose (50mg/ml). (D) Differential counts (2way ANOVA for panel B and D, 1way ANOVA for panel C, ***p < 0.001, **p<0.01, *p<0.05)