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. 2013 Jan;32(1):21–30. doi: 10.5732/cjc.011.10245

Figure 2. Epigenetic regulation of gene expression.

Figure 2.

Promoter region of tumor suppressor gene is unmethylated in normal cells and methylated in cancer cells. Filled cycles represent methylated DNA; unfilled cycles represent unmethylated DNA. Blue cylinder represents active histone modification; red cylinder represents repressive histone modification. 1, 2 and 3 represent exons 1, 2 and 3. HMT, histone methyltransferase; HAT, histone acetylase; DNMT, DNA methyltransferase; MBP, methyl-CpG binding protein; HDAC, histone deacetylase; TF, transcription factors; CA, co-activator; CR, co-repressor; Ac, acetylation; 4M, H3K4 methylation.