Fig. 2.—

Variability in the length of the RING domain. The RING domains from 67 annotated human TRIM genes were collected from Ensembl (Flicek et al. 2012) and GenBank and evaluated to determine the length of the variable loop 2 region located within the domain. Alignments of homologous regions were built using ClustalX (Larkin et al. 2007) and the number of residues residing in the variable region were counted. The predicted length of this variable region ranges from 4 to 48 amino acids. TRIM52 and TRIM41 have the largest expansion of their RING domains.