Table 1.
Key Features of C. jejuni IA3902 Revealed by Combined Analysis of the Genomic, Transcriptomic and Proteomic Data
| Features of IA3902 Revealed by Muti-omics Approaches | Potential Implication for IA3902 Pathogenesis | |
|---|---|---|
| Comparative genomics | Unique genes in O-linked glycosylation | Flagellar modification, host cell specificity, colonization, and translocation |
| Unique genes in capsule biosynthesis and modification | Serum resistance and bacteremia induction | |
| fspA2 | Tissue damage | |
| tetO | Antibiotics resistance and persistence | |
| SNPs and indels | Global regulation of gene expression | |
| Transcriptomics | ↓ Iron uptake systems | Adaptation to iron-limited condition |
| ↑ Energy production and conversion | Motility, colonization, and translocation | |
| ↑ Cell motility | ||
| ↑ Anaerobic respiration | Adaptation to oxygen limitation | |
| ↑ Serine utilization | Selective utilization of amino acid and growth in different tissues | |
| ↓ Proline, glutamate, aspartate, and lactate utilization | ||
| Proteomics | ↓ P19 | Adaptation to iron-limited condition |
| ↓ CfrA | ||
| ↓ ChuZ | ||
| ↓ChuA | ||
| ↑ PseC | Flagellar modification and host cell specificity | |
Note.—Genes with increased mRNA or protein expression in IA3902 are indicated by upward arrows and those with decreased mRNA or protein expression in IA3902 are indicated by downward arrows.