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. Author manuscript; available in PMC: 2014 Sep 11.
Published in final edited form as: J Am Chem Soc. 2013 Aug 28;135(36):10.1021/ja403412y. doi: 10.1021/ja403412y

Figure 1.

Figure 1

a) Overview of the FUSION assay to link natural products molecular target or pathway. HCT-116 cells were individually subjected to chemical and genetic perturbations and analyzed for their gene expression of a set of select genes. b) Hierarchical clustering of natural product fractions with discoidin domain receptor 2 (DDR2) based on gene expression of six genes. c) 2D-Matrigel cell migration assay with BR5 fibroblasts, platelet derived growth factor and a natural product fraction from B. hunanensis SNA-048 (fraction 7) at 1 μg/mL.