Figure 6.
a) Quantification of migration inhibition in a BR5 2D-Matrigel fibroblast migration assay with 1 μM of 1 – 4 + platelet derived growth factor, DMSO as a negative control and 0.1 μM dasatinib (0.1 μM) as a positive control. To ensure activity was not due to cell death, cell viability of BR5 fibroblasts was measured by Cell Titer-glo® at the same concentration. b) Dose-dependent effect of 1 on DDR2 in BR5 fibroblasts.