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Mean lesion area expressed as % lesion area of total area of the aorta at 14 weeks (4a; male and female) and 24 weeks (4b; female). *Significant difference (p≤0.05). Kaplan Meier survival curve (4c) of “western-type” diet fed apoE KO (n=31) and apoE/nNOS-DKO (n=42) animals showing a pronounced decrease in late survival of apoE/nNOS DKO animals (p=0.0003).
