Table 4.
Associations of Transient Changes in Affective Distress and Time-dependent Variables
| Models for all observations | Coefficient | Coefficient P-value | Model Adjusted R2 | Model P-value |
|---|---|---|---|---|
| POMS Total Mood Disturbance | .128 | <.001 | ||
| Current MDD | 1.365 | <.001** | ||
| Interval METH quantity (log10) | .064 | .158 | ||
|
| ||||
| POMS Tension-Anxiety | .104 | <.001 | ||
| Current MDD | .644 | <.001** | ||
| Interval METH quantity (log10) | .044 | .075 | ||
|
| ||||
| POMS Depression-Dejection | .116 | <.001 | ||
| METH dependence | −.200 | .068 | ||
| Current MDD | .907 | <.001** | ||
| Days since last METH use (log10) | −.200 | <.001** | ||
|
| ||||
| POMS Anger-Hostility | ||||
| METH dependence | −.190 | .107 | ||
| Current MDD | .718 | <.001** | ||
| Days since last METH use (log10) | −.098 | .056 | ||
|
| ||||
| POMS Vigor-Activation | .040 | <.001 | ||
| Current MDD | −2.500 | <.001** | ||
|
| ||||
| POMS Fatigue-Inertia | .065 | <.001 | ||
| Current MDD | .590 | <.001** | ||
| Interval METH quantity (log10) | .042 | .139 | ||
|
| ||||
| POMS Confusion-Bewilderment | .103 | <.001 | ||
| METH dependence | −.084 | .153 | ||
| Current MDD | .502 | <.001** | ||
| Interval METH quantity (log10) | .044 | .039* | ||
|
| ||||
| Models for HIV+ observations only | Coefficient | Coefficient P-value | Model Adjusted R2 | Model P-value |
|
| ||||
| POMS Total Mood Disturbance | .148 | <.001 | ||
| METH dependence | .218 | .339 | ||
| Current MDD | 2.476 | <.001** | ||
| METH-MDD interaction | −1.500 | .010** | ||
|
| ||||
| POMS Tension-Anxiety | .115 | <.001 | ||
| Current MDD | .639 | <.001** | ||
| Interval METH quantity (log10) | .062 | .083 | ||
| HIV Plasma Viral Load | .073 | .059 | ||
|
| ||||
| POMS Depression-Dejection | .101 | <.001 | ||
| Current MDD | .844 | <.001** | ||
| Days since last METH use (log10) | −.140 | .026* | ||
|
| ||||
| POMS Anger-Hostility | .069 | <.001 | ||
| Current MDD | .719 | .001** | ||
| HIV CSF Viral Load | .138 | .071 | ||
|
| ||||
| POMS Vigor-Activation | .067 | <.001 | ||
| Current MDD | −3.000 | <.001** | ||
|
| ||||
| POMS Fatigue-Inertia | .074 | <.001 | ||
| Current MDD | .646 | <.001** | ||
|
| ||||
| POMS Confusion-Bewilderment | .093 | <.001 | ||
| METH dependence | −.025 | .764 | ||
| Current MDD | .887 | <.001** | ||
| METH-MDD interaction | .−590 | .012* | ||
Note: CSF = Cerebrospinal Fluid; HIV = Human Immunodeficiency Virus; METH = Methamphetamine; MDD = major depressive disorder; POMS = Profile of Mood States. Time-dependent variables are those that vary with time.