Table I.
Genes and pathways in follicular cells.
| Study | Cell type | Methods used | Selection measure | Genes | Function | Expression pattern |
|---|---|---|---|---|---|---|
| Kõks et al. (2010) | FGCs | Microarray | Global gene expression analysis | SCP2 | Steroidogenesis | Up-regulated |
| CYP11A1 | Up-regulated | |||||
| CYP17A1 | Up-regulated | |||||
| Grøndahl et al. (2012) | Granulosa and CCs | Microarray and real-time PCR | Global gene expression analysis before ovulation | CYP11A1 | Steroidogenesis | Up-regulated in GCs |
| GHR | Proliferation and metabolism | Up-regulated in GCs | ||||
| GAP43 | Proliferation and metabolism | Up-regulated in CCs | ||||
| RYR2 | Cell–cell communication | Up-regulated in CCs | ||||
| CACNA1C | Cell–cell communication | Down-regulated in GCs and up-regulated in CCs | ||||
| TNC | Extracellular matrix | Down-regulated in GCs and up-regulated in CCs | ||||
| ESR1 | Gonadotrophin, steroid hormone, steroidogenesis and nuclear receptors | Up-regulated in GCs and CCs | ||||
| Pacella et al. (2012) | GCs | Real-time PCR | Female age and ovarian reserve | PFKP | Glycolysis | Up-regulated in relation to advancing female age or reduced ovarian reserve |
| LDHA | ||||||
| McReynolds et al. (2012) | CCs | LC-MS/MS and real-time PCR | Female age | CYP11A1 | Steroidogenesis | Down-regulated with advancing female age |
| VCAN | Extracellular matrix | Down-regulated with advancing female age | ||||
| ATP5I, NDUFA1, ATP6V1A and COX10 | Oxidative phosphorylation and mitochondrial function | Down-regulated with advancing female age | ||||
| SFPQ, KHSRP, DDX46 and SNRPF | Post-transcriptional slicing | Down-regulated with advancing female age | ||||
| ACAT2, HSD17B4 | Amino acid metabolism | Up-regulated with advancing female age | ||||
| Fragouli et al. (2012) | CCs | Microarray and real-time PCR | Oocyte chromosome status | SPSB2 | Ubiquitination | Down-regulated in CCs of aneuploid oocytes |
| TP53I3 | DNA damage response | Down-regulated in CCs of aneuploid oocytes | ||||
| de los Santos et al. (2012) | CCs | Microarray and real-time PCR | Natural versus COS cycles | MYH11 | Angiogenesis | Up-regulated in natural cycles |
| SOX4 | Leukocyte differentiation and T-cell activation | Up-regulated in natural cycles | ||||
| PRB2 | Not specified | Up-regulated in COS cycles |
CC, cumulus cells; COS, controlled ovarian stimulation; FGC, floating granulosa cell; GC, granulosa cell.