Table 2.
Pulmonary function tests, muscle strength, thyroid function tests, SF-36 results and acute exacerbation frequency of COPD patients with and without hypothyroidism (Group 1 and 2)
| PARAMETERS |
COPD + Hypothyroidism |
COPD |
P |
|---|---|---|---|
|
Group 1 |
Group 2 |
||
| (n = 44) | (n = 44) | ||
| FEV1/FVC |
67.2 ± 11.1 |
53.2 ± 15.6 |
0.001 |
| FEV1(L) |
2.1 ± 0.7 |
2.01 ± 0.53 |
0.637 |
| FEV1(%) |
83.1 ± 22.2 |
77.5 ± 16.2 |
0.339 |
| FVC (L) |
3.1 ± 0.9 |
3.67 ± 0.9 |
0.041 |
| FVC (%) |
100.1 ± 19.2 |
108.9 ± 21 |
0.15 |
| FEF25–75 (%) |
47.5 ± 27.4 |
29.6 ± 12.3 |
0.009 |
| TLC (%) |
107.2 ± 19.5 |
105.3 ± 19 |
0.76 |
| TLC (L) |
5.9 ± 1.4 |
6.5 ± 1.5 |
0.306 |
| MIP (cmH2O) |
69.6 ± 30.7 |
67.3 ± 17.5 |
0.77 |
| MEP (cmH2O) |
25.6 ± 9.1 |
34.9 ± 11.5 |
0.006 |
| TSH (mIU/mL) |
4.3 (0.1–16.8) |
0.8(0.3-3.6) |
0.04 |
| FT4 (pmol/L) |
2.15 ± 3.27 |
2.36 ± 3.56 |
0.87 |
| FT3 (pmol/L) |
2.37 ± 0.77 |
2.73 ± 0.84 |
0.27 |
| Acute exacerbation frequency (/years) |
1.5 ± 0.85 |
0.86 ± 0.83 |
0.017 |
| General health |
35 (0–80) |
45 (10–70) |
0.383 |
| Physical functioning |
52.5 (0–100) |
62.5 (25–95) |
0.391 |
| Physical role limitation |
25 (0–100) |
25 (0–100) |
0.637 |
| Emotional role limitation |
33 (0–100) |
33 (0–100) |
0.608 |
| Social functioning |
50 (13–100) |
56 (0–100) |
0.972 |
| Pain |
60 (0–100) |
85 (20–100) |
0.179 |
| Vitality |
52.5 (10–85) |
57.5 (20–92) |
0.548 |
| Mental health | 52.5 (12–80) | 58 (15–90) | 0.249 |
Data are expressed as mean ± SD for parameters with normal distribution and median for parameters with skewed distribution (range min-max).
COPD, Chronic obstructive pulmonary disease; FEF25–75%, Forced expiratory flow at 25–75%; FEV1, Forced expiratory volume at 1 second; FT3, Free triiodothyronine; FT4, Free tetraiodothyronine; FVC, Forced vital capacity; MEP, Maximal expiratory pressure; MIP, Maximal inspiratory pressure; SF-36, Short form-36; TSH, Thyroid stimulating hormone.