Table 1.
Synergistic effect of TRAIL combined with 5-Fu on AGS cells analyzed by Jin's formula (Q value listed in the table).
| 5-Fu (μg/mL) | TRAIL (μg/mL) | |||
|---|---|---|---|---|
| 0.4 | 2 | 10 | 50 | |
| 0.05 | 0.88 | 0.95 | 0.91 | 0.84 |
| 0.1 | 0.94 | 0.99 | 0.92 | 0.91 |
| 0.5 | 1.03 | 1.20# | 1.06 | 0.98 |
| 1 | 1.15# | 1.17# | 1.12 | 1.12 |
| 5 | 1.16# | 1.22# | 1.17# | 1.02 |
According to Jin's formula, Q < 0.85 indicates antagonism, 0.85 ≤ Q < 1.15 indicates additive effects, and Q ≥ 1.15 indicates synergism (#). Synergism indicates that the effect of a mixture exceeds that expected from the individual components and additive effects (noninteraction) mean that the combined effect is equal to the expectation.