Table 3.

Response to Methacholine Challenge 1 Hour After Dosing in the 10 Study Patients

Patient No.	PC20 (mg/ml)		PC20 Ratio, 24 μg:12 μg	Fold Change in PC20 from Screening
	12 μg	24 μg		12 μg	24 μg
3	1.29	2.17	1.68	2.10	3.60
7	27.75	64.00	2.30	44.80	103.00
12	2.03	7.71	3.80	4.80	18.30
13	43.30	64.00	1.48	9.21	13.62
20	34.80	52.50	1.50	57.10	86.10
21	3.19	8.40	2.60	2.30	6.10
29	1.47	1.57	1.07	4.30	4.60
30	30.75	64.00	2.08	13.50	28.20
31	18.00	64.00	3.60	3.80	13.62
36	1.24	4.30	3.46	1.00	3.50
	Geometric Mean (95% confidence interval)
	7 (2–22)	16 (5–45)a	2.2 (1.6–3.0)	6 (2–16)	14 (6–33)

PC₂₀ = provocational concentration of methacholine required to decrease forced expiratory volume in 1 second by 20%.

^ap≤0.001.