Table IV.
Association of baseline plasma CRP levels and subsequent risk of colorectal cancer by time interval between blood collection and cancer diagnosis: SMHS (2002–06)a
| Interval (years) |
CRP (μg/ml),
geometric mean (95% CI) |
P | CRP (μg/ml) | P trend | ||
| <0.45 | 0.45–1.19 | >1.19 | ||||
| All participants | ||||||
| <2 years | ||||||
| Colorectal cancer cases | 1.28 (0.98–1.66) | 13 | 24 | 40 | ||
| Controls | 0.86 (0.72–1.03) | 0.020 | 48 | 53 | 53 | |
| RR (95% CI) | 1.0 | 1.77 (0.74–4.24) | 3.28 (1.28–8.37) | 0.012 | ||
| 2–4 years | ||||||
| Colorectal cancer cases | 0.86 (0.69–1.09) | 20 | 27 | 39 | ||
| Controls | 0.66 (0.56–0.78) | 0.068 | 74 | 52 | 46 | |
| RR (95% CI) | 1.0 | 2.40 (1.06–5.39) | 3.68 (1.62–8.38) | 0.002 | ||
| >4 years | ||||||
| Colorectal cancer cases | 0.99 (0.83–1.18) | 27 | 43 | 55 | ||
| Controls | 0.87 (0.77–0.98) | 0.236 | 70 | 86 | 94 | |
| RR (95% CI) | 1.0 | 1.16 (0.62–2.18) | 1.05 (0.56–1.97) | 0.942 | ||
| Excluding participants who had used antibiotics in the 7 days before blood collection | ||||||
| <2 years | ||||||
| Colorectal cancer cases | 1.21 (0.93–1.58) | 12 | 23 | 35 | ||
| Controls | 0.88 (0.73–1.06) | 0.061 | 45 | 51 | 48 | |
| RR (95% CI) | 1.0 | 2.14 (0.82–5.57) | 3.43 (1.17–10.0) | 0.025 | ||
| 2–4 years | ||||||
| Colorectal cancer cases | 0.87 (0.70–1.10) | 18 | 26 | 35 | ||
| Controls | 0.64 (0.55–0.75) | 0.032 | 70 | 49 | 42 | |
| RR (95% CI) | 1.0 | 2.65 (1.08–6.50) | 4.73 (1.90–11.8) | 0.001 | ||
| >4 years | ||||||
| Colorectal cancer cases | 0.93 (0.78–1.12) | 26 | 40 | 47 | ||
| Controls | 0.87 (0.76–0.98) | 0.524 | 63 | 80 | 88 | |
| RR (95% CI) | 1.0 | 1.07 (0.55–2.07) | 0.95 (0.48–1.87) | 0.833 | ||
aRRs and geometric means were stratified by matched sets and adjusted for smoking status, regular exercise, BMI, WHR, family history of cancer, number of selected diseases reported at baseline, use of antibiotics in the 7 days before blood collection, use of antihypertension medication, and ever use of non-steroidal anti-inflammatory drugs.