. Author manuscript; available in PMC: 2013 Dec 2.

Published in final edited form as: Chem Res Toxicol. 2009 Jul;22(7):10.1021/tx900127s. doi: 10.1021/tx900127s

Table 3. Correlation between IC₅₀ values for EROD inhibition and spectral parameters (Ks, ΔAmax, and ΔAmax/Ks) with various groups of chemical inhibitors in human P450 1B1 enzyme system.

Chemicals	Comparison	correlation coefficient (r)
Total (n=49)	IC₅₀ vs K_s	0.72
	IC₅₀ vs ΔA_max	0.21
	IC₅₀ vs ΔA_max/K_s	0.74
flavonoids, stilbenes, E1, and E2 (n=20)	IC₅₀ vs K_s	0.81
	IC₅₀ vs ΔA_max	0.29
	IC₅₀ vs ΔA_max/K_s	0.86
biphenyls (n=10)	IC₅₀ vs K_s	0.75
	IC₅₀ vs ΔA_max	0.12
	IC₅₀ vs ΔA_max/K_s	0.89
pyrenes (n=6)	IC₅₀ vs K_s	0.78
	IC₅₀ vs ΔA_max	0.52
	IC₅₀ vs ΔA_max/K_s	0.55
naphthalene (n=6)	IC₅₀ vs K_s	0.42
	IC₅₀ vs ΔA_max	0.60
	IC₅₀ vs ΔA_max/K_s	0.33
phenanthrenes (n=7)	IC₅₀ vs K_s	0.80
	IC₅₀ vs ΔA_max	0.43
	IC₅₀ vs ΔA_max/K_s	0.77

Table 3. Correlation between IC50 values for EROD inhibition and spectral parameters (Ks, ΔAmax, and ΔAmax/Ks) with various groups of chemical inhibitors in human P450 1B1 enzyme system.