Table 1. Experimental design: factors and responses.
| Independent variables | -1 | 0 | +1 |
| X1: Ratio of Eudragit S100: RS100 | 20:80 | 60:40 | 100:0 |
| X2: Drug:polymer ratio | 1:1 | 1.5:1 | 2:1 |
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