Table 1. Evaluation of analgesic activity by acetic acid induced writhing method.
Sr. No. | Treatment | Dose mg/kg | Writhing episodes in 15 min (Mean ± S.E.M.) | Percent protection |
1 | Control | -- | 38.70±0.5547 | - |
2 | Ibuprofen | 10 | 13.19±0.6921** | 66 |
3 | IIIa | 50 | 17.28±0.6647** | 55 |
4 | IIIb | 50 | 18.24±0.6425** | 53 |
5 | IIIc | 50 | 24.89±0.5354** | 36 |
6 | IIId | 50 | 15.65±0.7845** | 60 |
7 | IIIe | 50 | 26.45±0.8121** | 32 |
8 | IIIf | 50 | 16.46±0.5744** | 57 |
9 | IIIg | 50 | 27.65±0.5478** | 29 |
10 | IIIh | 50 | 18.57±0.4545** | 52 |
11 | IIIi | 50 | 16.49±0.6545** | 57 |
12 | IIIj | 50 | 16.47±0.2254** | 57 |
13 | IVa | 50 | 16.45±0.5456** | 57 |
14 | IVb | 50 | 17.49±0.5641** | 55 |
15 | IVc | 50 | 21.73±0.5974** | 44 |
16 | IVd | 50 | 15.44±0.6133** | 60 |
17 | IVe | 50 | 22.45±0.5525** | 42 |
18 | IVf | 50 | 15.36±0.6455** | 60 |
19 | IVg | 50 | 19.65±0.7322** | 49 |
20 | IVh | 50 | 17.22±0.4855** | 56 |
21 | IVi | 50 | 19.47±0.6513** | 50 |
22 | IVj | 50 | 14.24±0.4745** | 63 |
23 | IV3a | 100 | 15.44±0.4454** | 60 |
24 | IV3b | 100 | 22.65±0.5546** | 42 |
25 | IV3c | 100 | 19.47±0.5941** | 50 |
26 | IV3d | 100 | 21.77±0.4423** | 44 |
27 | IV3e | 100 | 25.49±0.4473** | 34 |
28 | IV3f | 100 | 19.42±0.6651** | 50 |
29 | IV3g | 100 | 26.56±0.4329** | 31 |
30 | IV3h | 100 | 28.56±0.7325** | 26 |
31 | IV3i | 100 | 23.58±0.6423** | 39 |
32 | IV3j | 100 | 19.26±0.4523** | 50 |
33 | Ih | 25 | 20.54±0.6425** | 47 |
34 | Ii | 25 | 22.89±0.5214** | 41 |
35 | Ij | 25 | 18.34±0.4527** | 53 |
36 | IIh | 25 | 20.57±0.8592** | 47 |
37 | IIi | 25 | 22.44±0.6854** | 42 |
38 | IIj | 25 | 15.47±0.8957** | 60 |
** P < 0.01 represent significant difference when compared with control groups. |