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Histograms of Rgfrom direct simulations at ø = 0.31 and predicted by postprocessing the crowder-free simulations (with ø= 0). Hard sphere: Δμ calculated by approximating the crowders as hard spheres; Inverse r12: Δμ calculated by exact treatment of the inverse r12 form of protein-crowder interactions. Results are for ξ = 0.7.
