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In vitro and in vivo anti-trypanosomal activity of 2,6-diarylpyrazine diamidines in the STIB900 mouse model.a
| Code | T. b. r. IC50(nM) |
Dosage (ip, mg/kg) b | Cures c | Survival (days) d |
|---|---|---|---|---|
| 1 | 2.2 | 20 | 2/4 | >57.5 |
| 5 | 1/4 | >38 | ||
| 2a | 4.5 | 20 | 3/4 | >57.75 |
| 5 | 1/4 | >46 | ||
| 3a | 6.5 | 20 | 4/4 | >60 |
| 5 | 3/4 | >54.5 | ||
| 4a | 21 | 20 | 4/4 | >60 |
| 5 | 3/4 | >49.5 | ||
| 6 | 18 | 5 | 0/4 | 36.5 |
| 10 | 5.8 | 5 | 3/4 | >53.5 |
| 15a | 462 | / | / | / |
| 15b | 27 | 5 | 0/4 | >41 |
| 19a | 14 | 5 | 4/4 | >60 |
| 19b | 6 | 5 | 2/4 | >60 |
| 23a | 37 | 5 | 2/4 | >53.75 |
| 23b | 4.8 | 5 | 1/4 | >36.5 |
