Figure 2. Overall survival after DLI according to initial CD3+ cell dose and disease risk category.
Low risk included CML-CP and CLL, MM, low-risk lymphomas. High risk included high risk myeloid malignancies (AML, MDS, CML –AP/BC), myelofibrosis, myeloproliferative disorders, and high risk lymphoid malignancies (ALL, High grade lymphomas (Hodgkin lymphoma, diffuse large B cell lymphoma, transformed non-Hodgkin lymphoma)).
a. Low risk category. 1- and 3-year overall survival were 94% and 73% for cell dose A, 67% and 53% for cell dose B and 60% and 55% for cell dose C (P =0.07).
b. High risk category. 1- and 3-year overall survival were 47% and 27% for cell dose A, 60% and 42% for cell dose B and 41% and 22% for cell dose C (P =0.35)