Table II.

Brain regions showing significant differences between PD patients and NL by different types of normalization.

Cluster extent	Coordinates*	Z †	Anatomical area	Brodmann area
GM normalization: Relative hypometabolism in PD patients as compared to NL
1749	−50 −70 5	6.09	Left middle occipital gyrus	37
	−55 −60 −4	5.93	Left inferior temporal gyrus	37
	−48 −55 18	4.66	Left superior temporal gyrus	22
106	−38 25 −11	5.36	Left inferior frontal gyrus	47
200	−63 −35 39	5.32	Left inferior parietal lobule	40
	−57 −49 36	4.69	Left supramarginal gyrus	40
67	50 5 26	4.56	Right inferior frontal gyrus	6
54	−46 3 24	4.92	Left inferior frontal gyrus	6
GM normalization: Relative hypermetabolism in PD patients as compared to NL
118	−20 27 −3	5.87	Left frontal lobe white matter
	−24 31 4	4.49	Left frontal lobe white matter
57	26 −15 41	4.86	Right frontal lobe white matter
	26 −27 40	4.16	Right frontal lobe white matter
617	−6 −40 −18	4.82	Left cerebellum (culmen)
	14 −51 −16	4.49	Right cerebellum (culmen)
180	28 −15 12	4.72	Right lentiform nucleus (putamen)
	34 −23 −2	4.70	Right caudate nucleus
WM normalization: Relative hypometabolism in PD patients as compared to NL
13350	−40 25 −10	6.62	Left inferior frontal gyrus	47
	−46 −70 7	6.24	Left middle occipital gyrus	19
	−46 35 −5	6.15	Left middle frontal gyrus	47
	−63 −39 39	6.10	Left inferior parietal lobule	40
	−48 −73 22	5.98	Left middle temporal gyrus	39
	−57 −57 −4	5.90	Left inferior temporal gyrus	37
	−53 −7 −21	5.90	Left inferior temporal gyrus	20
	−55 −60 −4	5.90	Left inferior temporal gyrus	37
	−50 −40 28	5.81	Left inferior parietal lobule	40
553	20 12 3	6.46	Right lentiform nucleus (putamen)
385	−16 12 3	6.24	Left lentiform nucleus (putamen)
4232	51 35 −7	6.02	Right inferior frontal gyrus	47
	51 3 24	5.88	Right inferior frontal gyrus	6
	51 27 28	5.76	Right middle frontal gyrus	9
	18 65 12	5.71	Right superior frontal gyrus	10
992	48 −64 3	5.72	Right middle temporal gyrus	37
	46 −78 −5	4.87	Right inferior occipital gyrus	19
896	14 −72 44	5.34	Right precuneus	7
	14 −90 27	5.00	Right cuneus	19
332	−10 61 14	5.18	Left superior frontal gyrus	10
	−8 52 36	4.52	Left superior frontal gyrus	9
	−8 47 42	4.39	Left superior frontal gyrus	8
165	−8 −19 −1	5.02	Left thalamus
	−18 −29 1	4.96	Left thalamus
201	14 −23 1	5.01	Right thalamus
318	53 4 −29	4.94	Right middle temporal gyrus	21
	57 −11 −20	4.79	Right inferior temporal gyrus	20
Yakushev normalization: Relative hypometabolism in PD patients as compared to NL
42086	−50 1 22	7.64	Left inferior frontal gyrus	44
	−40 25 −11	7.25	Left inferior frontal gyrus	47
	−46 −68 3	7.16	Left middle occipital gyrus	37
	−57 −58 −2	6.99	Left inferior temporal gyrus	37
	−55 −62 −2	6.98	Left middle temporal gyrus	37
	−42 −19 −26	6.72	Left inferior temporal gyrus	20
	−53 −7 −22	6.58	Left inferior temporal gyrus	20
	−46 37 −7	6.28	Left middle frontal gyrus	47
	−63 −35 37	6.28	Left inferior parietal lobule	40
	−48 −43 28	6.27	Left inferior parietal lobule	40
	−59 −47 37	6.21	Left supramarginal gyrus	40
12772	55 15 24	7.17	Right inferior frontal gyrus	44
	14 −72 46	6.48	Right precuneus	7
	50 −68 3	6.41	Right middle occipital gyrus	37
	51 28 24	6.23	Right middle frontal gyrus	46
	50 37 −7	6.09	Right middle frontal gyrus	47
	18 65 10	5.92	Right superior frontal gyrus	10
	38 32 28	5.87	Right middle frontal gyrus	9
	55 −11 −20	5.65	Right inferior temporal gyrus	20
	53 4 −29	5.32	Right middle temporal gyrus	21
	51 −27 3	5.18	Right superior temporal gyrus	22
	63 −31 38	4.83	Right inferior parietal lobule	40
900	−8 61 17	5.69	Left superior frontal gyrus	10
	−10 45 42	5.38	Left superior frontal gyrus	8
	−6 40 16	5.06	Left anterior cingulate	32
258	−18 −29	0 6.37	Left thalamus
253	16 −25 1	5.95	Right thalamus
232	−14 10 3	5.97	Left caudate nucleus
	−20 8 1	5.91	Left lentiform nucleus (putamen)
245	25 10 3	6.20	Right lentiform nucleus (putamen)
	10 15 4	5.84	Right caudate nucleus
202	14 34 20	5.47	Right anterior cingulate	32

^*Coordinates (x, y, z) from Talairach and Tournoux

^†Z values at the peak of maximum significance at P<0.05, FWE corrected.

GM: global grey matter mean; NL: normal controls; PD: Parkinson’s disease patients; WM: white matter.