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Mouse PK Resultsa
| 24 VU0409106b | 28 VU0415303c | |
|---|---|---|
| Plasma Tmax (h) | 0.25 | 0.5 |
| Plasma Cmax (ng/mL) | 1450 | 303 |
| Brain Tmax (h) | 0.25 | 0.25 |
| Brain Cmax (ng/g) | 1350 | 311 |
| AUCplasma (ng·h/mL) | 702 | 391 |
| AUCbrain (ng·h/g) | 696 | 365 |
| B/P ratio | 0.99 | 0.93 |
10 mg/kg IP dose; 10% Tween 80 formulation
CD-1 mice (n=3 per time point)
CD-1 mice (n=2 per time point)
